Abstract
Benign fibroepithelial lesions of the oral cavity, commonly referred to as irritation fibroma, traumatic fibroma, or focal fibrous hyperplasia, represent reactive proliferations arising in response to chronic tissue injury. While their clinical and histopathological features are well established, hyalinized variants are exceptionally rare and sparsely documented in the literature. Here, we present a case of a hyalinized fibroepithelial lesion of the oral mucosa, initially presenting as a nonspecific pedunculated nodular mass. The lesion was surgically excised, and histopathological examination revealed dense collagen deposition with prominent hyalinization, confirming the diagnosis. A brief review of previously reported cases is also provided to highlight the diagnostic challenges and clinical implications of this unusual histological presentation. This report underscores the importance of considering hyalinized variants in the differential diagnosis of oral soft tissue lesions and reaffirms surgical excision with elimination of irritative factors as the treatment of choice.

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Copyright (c) 2025 Safiye Pelin Şahiner, Gözde Serindere, Cansel Coşar, Figen Öngöz Dede, Büşra Erşan Erdem
